HI-Floxin may be available in the countries listed below.
Ciprofloxacin hydrochloride (a derivative of Ciprofloxacin) is reported as an ingredient of HI-Floxin in the following countries:
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Talpramin may be available in the countries listed below.
Imipramine hydrochloride (a derivative of Imipramine) is reported as an ingredient of Talpramin in the following countries:
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Tanatril may be available in the countries listed below.
UK matches:
Imidapril is reported as an ingredient of Tanatril in the following countries:
Imidapril hydrochloride (a derivative of Imidapril) is reported as an ingredient of Tanatril in the following countries:
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Glossary
| SPC | Summary of Product Characteristics (UK) |
Somatostatina Normon may be available in the countries listed below.
Somatostatin x acetate (a derivative of Somatostatin) is reported as an ingredient of Somatostatina Normon in the following countries:
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Demovit C may be available in the countries listed below.
Ascorbic Acid is reported as an ingredient of Demovit C in the following countries:
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Meto Zerok may be available in the countries listed below.
Metoprolol succinate (a derivative of Metoprolol) is reported as an ingredient of Meto Zerok in the following countries:
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In some countries, this medicine may only be approved for veterinary use.
0000125-46-2
C18-H16-O7
344
Antibacterial
2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,2,3,9b-tetrahydrodibenzofuran-1,3-dione
2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,3(2H,9bH)-dibenzofurandione
2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,3(2H,9bh)-dibenzofurandione (IUPAC)
International Drug Name Search
Glossary
| IUPAC | International Union of Pure and Applied Chemistry |
| IS | Inofficial Synonym |
Restamin may be available in the countries listed below.
Diphenhydramine is reported as an ingredient of Restamin in the following countries:
Diphenhydramine hydrochloride (a derivative of Diphenhydramine) is reported as an ingredient of Restamin in the following countries:
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Indometacina may be available in the countries listed below.
Indometacina (DCIT) is also known as Indometacin (Rec.INN)
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Glossary
| DCIT | Denominazione Comune Italiana |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
Ritmonorm may be available in the countries listed below.
Propafenone hydrochloride (a derivative of Propafenone) is reported as an ingredient of Ritmonorm in the following countries:
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Class: Adamantanes
VA Class: AM800
Chemical Name: α-Methyl tricyclo[3.3.1.13,7]decane-1-methanamine hydrochloride
Molecular Formula: C12H21N•HCl
CAS Number: 1501-84-4
Brands: Flumadine
Antiviral; adamantane derivative.1 3 10 15 16 40 42
Symptomatic treatment of uncomplicated illness caused by susceptible influenza A virus.1 2 3 5 11 15 16 33 37 61
Consider viral surveillance data available from local and state health departments and the CDC when selecting an antiviral for treatment of seasonal influenza.116 137 149 Strains of circulating influenza viruses and the antiviral susceptibility of these strains constantly evolve,116 144 and emergence of rimantadine-resistant influenza virus may decrease effectiveness of the drug.1
Beginning in the 2005–2006 influenza season, most influenza A (H3N2) strains circulating in the US were resistant to adamantanes (amantadine, rimantadine),29 77 116 121 and resistance to the drugs among seasonal influenza A (H3N2) isolates has remained high during subsequent influenza seasons.29 117 162 In addition, the 2009 pandemic influenza A (H1N1) virus was resistant to amantadine and rimantadine,52 117 151 162 and this strain is expected to continue to circulate during the 2010–2011 influenza season.144 162
Amantadine and rimantadine have little or no activity against influenza B.1 11 15 16 35 42
CDC recommends that adamantanes (amantadine, rimantadine) not be used for the treatment of influenza in the US until susceptibility to these antiviral agents has been reestablished in circulating influenza A viruses.77
CDC issues recommendations concerning the use of antiviral agents for the treatment of influenza, and these recommendations are updated as needed during each influenza season.144 Information regarding influenza surveillance and updated recommendations for treatment of seasonal influenza are available from CDC at .
Prophylaxis of influenza infection caused by susceptible influenza A when timely vaccination with influenza virus vaccine is not feasible, contraindicated, or not available.1 3 4 7 8 16 47
Annual vaccination with seasonal influenza virus vaccine, as recommended by the US Public Health Service Advisory Committee on Immunization Practices (ACIP), is the primary means of preventing seasonal influenza and its severe complications.1 29 116 144 149 161 Prophylaxis with an appropriate antiviral active against circulating influenza strains is considered an adjunct to vaccination for control and prevention of influenza in certain individuals.1 29 116 144 149 161
Consider viral surveillance data available from local and state health departments and the CDC when selecting an antiviral for the prophylaxis of influenza.116 137 149 The most appropriate antiviral for prevention of influenza is selected based on information regarding the likelihood that the influenza strain is susceptible and the known adverse effects of the drug.137 144 Strains of circulating influenza viruses and the antiviral susceptibility of these strains constantly evolve,137 144 and emergence of rimantadine-resistant influenza virus may decrease effectiveness of the drug.1
CDC recommends that adamantanes (amantadine, rimantadine) not be used for prevention of influenza in the US until susceptibility to these antiviral agents has been reestablished in circulating influenza A viruses.77
CDC issues recommendations concerning the use of antiviral agents for prophylaxis of influenza, and these recommendations are updated as needed during each influenza season.144 Information regarding influenza surveillance and updated recommendations for prevention of seasonal influenza are available from CDC at .
May be used for treatment or prophylaxis of avian influenza A virus infections† in certain situations.94 104
The WHO recommends use of a neuraminidase inhibitor (i.e., oseltamivir) for the treatment of avian influenza A infections.94 104
Concomitant use of a neuraminidase inhibitor (i.e., oseltamivir) and an adamantane (amantadine, rimantadine) can be considered in a patient with pneumonic disease or clinical progression if local surveillance data indicate the H5N1 virus is known or likely to be susceptible to an adamantane.104
Should not be used alone for treatment of avian influenza A if a neuraminidase inhibitor is available.94 104
Administer orally without regard to meals.1 14
Dosages <150 mg daily can be given as a single dose; dosages of 200 mg daily can be given in 2 divided doses.1 23 Dividing dosages >100 mg daily into 2 doses may minimize adverse effects.63
Available as rimantadine hydrochloride; dosage expressed in terms of rimantadine hydrochloride.1
Children ≥13 years of age†: 100 mg twice daily.29
Initiate rimantadine treatment as soon as possible, preferably within 24–48 hours after onset of symptoms and continue for up to 5 days or 24–48 hours after symptoms disappear.1
Children 1–9 years of age: 5 mg/kg (maximum 150 mg) once daily.1 29
Children ≥10 years of age: 100 mg twice daily.1 AAP recommends 5 mg/kg daily in 2 divided doses in those weighing <40 kg or 100 mg twice daily in those weighing ≥40 kg.29
Individualize duration of prophylaxis. For maximum effectiveness, must be taken every day during influenza activity in the community. Manufacturer states that safety and efficacy for >6 weeks not established.1
100 mg twice daily.1 28
Initiate rimantadine treatment as soon as possible, preferably within 24–48 hours after onset of symptoms and continue for up to 5 days or 24–48 hours after symptoms disappear.1
100 mg twice daily.1 28
Duration of antiviral prophylaxis should be individualized. For maximum effectiveness, the antiviral agent must be taken every day during influenza activity in the community. Manufacturer states that safety and efficacy for >6 weeks not established.1
For prophylaxis in conjunction with influenza virus vaccine (see Specific Drugs under Interactions), rimantadine should be administered for 2 weeks after vaccine administration.1
Children 1–9 years of age: Maximum 150 mg daily.1 29
100 mg daily in patients with severe hepatic impairment.1
100 mg daily in patients with severe renal impairment (Clcr ≤10 mL/minute).1 Further dosage adjustments may be needed.1
≥65 years of age: 100 mg daily recommended by the manufacturer;1 ACIP and others recommend 100 mg daily in those who experienced adverse effects with the usual adult dosage.28
Geriatric individuals residing in nursing homes: 100 mg daily.1
Known hypersensitivity to adamantane derivatives (rimantadine, amantadine) or any ingredient in the formulation.1
Patients with a history of seizure disorders should be observed closely for possible increased seizure activity.1 Discontinue if seizures occur.1
Not effective for treatment or prophylaxis of viral respiratory tract illnesses other than those due to influenza A virus.1
Serious bacterial infections may present with influenza-like symptoms, coexist with influenza, or occur during influenza.25 73
Ensure accuracy of prescription; similar spelling of Flumadine (rimantadine) and flutamide may result in errors.1
Category C.1
Distributed into milk in rats; adverse effects noted in the offspring of rats given the drug during the perinatal and postnatal period.1 Use not recommended.1
Used in children ≥1 year of age for prophylaxis of influenza A;1 has not been evaluated for prophylaxis in infants <1 year of age.1
Safety and efficacy for treatment of influenza A virus infection not established in children.1 Has been used for the treatment of influenza A infection in children 1–15 years of age; safety and efficacy similar to that in adults.37 59 61
Frequency and severity of adverse effects, including adverse CNS effects, in individuals >65 years of age receiving rimantadine hydrochloride 100 mg twice daily higher than in younger adults and children.1 47
Consider age-related decreases in renal function when selecting dosage.1 (See Geriatric Patients under Dosage and Administration.)
Caution in patients with hepatic impairment.1 (See Hepatic Impairment under Dosage and Administration.)
Caution in patients with renal impairment.1 (See Renal Impairment under Dosage and Administration.)
Nausea,1 3 9 37 47 53 insomnia,1 3 40 47 53 dizziness.1 3 19 25 40 47 53
Drug | Interaction | Comments |
|---|---|---|
Acetaminophen | Slightly decreased rimantadine peak plasma concentrations and AUC1 | |
Aspirin | Slightly decreased rimantadine peak plasma concentrations and AUC1 | |
Cimetidine | Decreased rimantadine clearance with single dose of cimetidine1 | Effect of long-term administration not evaluated1 |
Influenza virus vaccines | Influenza virus vaccine inactivated: Rimantadine does not interfere with the antibody response to the vaccine1 Influenza virus vaccine live intranasal: Potential interference with antibody response to the live vaccine; no specific studies1 144 | Influenza virus vaccine inactivated: May be used concomitantly with or at any interval before or after rimantadine1 144 Influenza virus vaccine live intranasal: Do not administer the live intranasal vaccine until at least 48 hours after rimantadine is discontinued; do not administer rimantadine until at least 2 weeks after administration of the live intranasal vaccine;1 144 repeat vaccination if influenza antiviral is given 2 days before to 14 days after the vaccine144 |
Well absorbed from GI tract; peak plasma concentrations usually attained within 6 hours.1 14 40 49 51
Commercially available tablets and oral solution are bioequivalent.1 56 60
Food does not appear to affect absorption.1 14
Not fully characterized.1 Distributed into nasal secretions.40 51 54
Crosses the placenta in rats; distributed into milk in rats.1 Not known whether rimantadine crosses the placenta or is distributed into human milk.1
40%.1 40
Extensively metabolized in the liver.1 40 55
Principally excreted in urine (74%) as metabolites and unchanged drug (25%).1 40 55
Not removed by hemodialysis.1
25–38 hours in adults and children.1 40 49 51 54 60
No change in pharmacokinetics in patients with chronic liver disease (mainly stabilized cirrhosis).1 Clearance reduced and half-life increased twofold in patients with severe hepatic impairment.1
In patients with renal impairment, half-life prolonged and clearance decreased.1 20
15–30°C.1
15–30°C.1
Adamantane-derivative (a symmetric tricyclic amine);1 3 10 15 16 40 42 structurally related to amantadine.2 3 4 5 8 10 15 16 17 40 42
Has antiviral activity against some strains of influenza A, including some strains of H1N1, H2N2, and H3N2.1 4 5 11 12 16 42 45
Has little or no activity against influenza B.1 11 15 16 35 42
Worldwide incidence of influenza A viruses resistant to adamantanes (amantadine, rimantadine) has increased over the last several years.84 92 121
Beginning in the 2005–2006 influenza season, most influenza A (H3N2) strains circulating in the US were resistant to amantadine and rimantadine.77 121 Resistance to amantadine and rimantadine among seasonal influenza A (H3N2) isolates has remained high during subsequent influenza seasons.29 93 117 162
Although amantadine and rimantadine were active against most seasonal influenza A (H1N1) viruses circulating in the US during the 2008–2009 and 2009–2010 influenza seasons,133 139 162 the 2009 pandemic influenza A (H1N1) virus is resistant to amantadine and rimantadine.52 117 151 162
Some strains of avian influenza A (H5N1) have been susceptible to rimantadine;38 39 other strains, including influenza A (H5N1) isolated from patients in Asia during 2004 and 2005, have been resistant.76
Rimantadine inhibits viral replication by interfering with the influenza A virus M2 protein, an integral membrane protein.1 11 15 16 41 42 46
Strains of influenza A virus with reduced susceptibility to rimantadine have been produced in vitro and have emerged during therapy with the drug.1 6 8 9 10 11 12 24 25 41 42 43 46
Rimantadine-resistant influenza A viruses also are resistant to amantadine.9 10 16 25 41 42 43 46 48
Importance of not getting up suddenly from a sitting or lying position; notify clinician if dizziness or lightheadedness occur.1
Importance of informing clinician of existing or contemplated concomitant therapy, including prescription and OTC drugs and dietary or herbal products, as well as any concomitant illnesses.1
Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.1
Importance of advising patients of other important precautionary information.1 (See Cautions.)
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name
Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|---|---|---|---|
Oral | Solution | 50 mg/5 mL | Flumadine Syrup | Forest |
Tablets, film-coated | 100 mg* | Flumadine | Forest | |
Rimantadine Hydrochloride Tablets |
This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.
Flumadine 100MG Tablets (CARACO): 14/$43.99 or 42/$109.97
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions December 2010. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.
† Use is not currently included in the labeling approved by the US Food and Drug Administration.
1. Forest Pharmaceuticals, Inc. Flumadine (rimantadine hydrochloride) tablets and syrup prescribing information. St Louis, MO: 2007 Apr.
2. Van Voris LP, Betts RF, Hayden FG et al. Successful treatment of naturally occurring influenza A/USSR/77 H1N1. JAMA. 1981; 245:1128-31. [IDIS 128645] [PubMed 7007668]
3. Dolin R, Reichman RC, Madore HP et al. A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection. N Engl J Med. 1982; 307:580-4. [IDIS 155775] [PubMed 7050702]
4. Clover RD, Crawford SA, Abell TD et al. Effectiveness of rimantadine prophylaxis of children within families. Am J Dis Child. 1986; 140:706-9. [IDIS 217594] [PubMed 3521258]
5. Hayden FG, Monto AS. Oral rimantadine hydrochloride therapy of influenza A virus H3N2 subtype infection in adults. Antimicrob Agents Chemother. 1986; 29:339-41. [IDIS 212795] [PubMed 3521480]
6. Hayden FG, Sperber SJ, Belshe RB et al. Recovery of drug-resistant influenza A virus during therapeutic use of rimantadine. Antimicrob Agents Chemother. 1991; 35:1741-7. [IDIS 287974] [PubMed 1952841]
7. Crawford SA, Clover RD, Abell TD et al. Rimantadine prophylaxis in children: a follow-up study. Pediatr Infect Dis J. 1988; 7:379-83. [PubMed 3292997]
8. Monto AS, Arden NH. Implications of viral resistance to amantadine in control of influenza A. Clin Infect Dis. 1992; 15:362-7. [IDIS 300188] [PubMed 1520770]
9. Hayden FG, Belshe RB, Clover RD et al. Emergence and apparent transmission of rimantadine-resistant influenza A virus in families. N Engl J Med. 1989; 321:1696-702. [IDIS 261720] [PubMed 2687687]
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12. Valette M, Allard JP, Aymard M et al. Susceptibilities to rimantadine of influenza A/H1N1 and A/H3N2 viruses isolated during the epidemics of 1988 to 1989 and 1989 to 1990. Antimicrob Agents Chemother. 1993; 37:2239-40. [IDIS 320620] [PubMed 8257151]
14. Wills RJ, Rodriguez LC, Choma N et al. Influence of a meal on the bioavailability of rimantadine • HCl. J Clin Pharmacol. 1987; 27:821-3. [IDIS 235710] [PubMed 3429689]
15. Hayden FG. Antiviral agents: other antiviral agents. In: Hardman JG, Goodman LS, Gillman A et al, eds. Goodman and Gilman’s the pharmacological basis of therapeutics. 9th ed. New York: McGraw-Hill; 1996:1209-11.
16. Anon. Amantadine (Symmetrel) and rimantadine (Flumadine). In: Mandell GL, Bennett JE, Dolin R, eds. Principles and practice of infectious diseases. 4th ed. New York: Churchill Livingstone; 1995:417-9.
17. Hayden FG, Gwaltney JM Jr, Van de Castle RL et al. Comparative toxicity of amantadine hydrochloride and rimantadine hydrochloride in healthy adults. Antimicrob Agents Chemother. 1981; 19:226-33. [IDIS 134392] [PubMed 7347558]
18. Hayden FG, Hoffman HE, Spyker DA. Differences in side effects of amantadine hydrochloride and rimantadine hydrochloride relate to differences in pharmacokinetics. Antimicrob Agents Chemother. 1983; 23:458-64. [IDIS 167347] [PubMed 6847173]
19. Millet VM, Dreisbach M, Bryson YJ. Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine. Antimicrob Agents Chemother. 1982; 21:1-4. [IDIS 143682] [PubMed 7044294]
20. Capparelli EV, Stevens RC, Chow MSS et al. Rimantadine pharmacokinetics in healthy subjects and patients with end-stage renal failure. Clin Pharmacol Ther. 1988; 43:536-41. [IDIS 242095] [PubMed 3365917]
22. Wills RJ, Belshe R, Tomlinsin D et al. Pharmacokinetics of rimantadine hydrochloride in patients with chronic liver disease. Clin Pharmacol Ther. 1987; 42:449-54. [IDIS 234784] [PubMed 3665342]
23. Forest Pharmaceuticals, New York NY: Personal communication.
24. Centers for Disease Control and Prevention. Guidelines for prevention of nosocomial pneumonia. MMWR Recomm Rep. 1997; 46(RR-1):40-43,64.
25. Centers for Disease Control and Prevention. Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2005;54(RR-8):1-40.
28. American College of Physicians Task Force on Adult Immunization and Infectious Diseases Society of America. Guide for adult immunization. 3rd ed. Philadelphia, PA: American College of Physicians; 1994:20-23,26,30,36,90-97.
29. American Academy of Pediatrics. 2009 Red Book. Report of the Committee on Infectious Diseases. 28th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2009.
30. Centers for Disease Control and Prevention, Atlanta, GA: Personal communication on influenza virus vaccine.
33. Doyle WJ, Skoner DP, Alper CM et al. Effect of rimantadine treatment on clinical manifestations and otologic complications in adults experimentally infected with influenza A (H1N1) virus. J Infect Dis. 1998; 177:1260-5. [IDIS 405278] [PubMed 9593010]
34. Nelson KE, Clements ML, Miotti P et al. The influence of human immunodeficiency virus (HIV) infection on antibody responses to influenza vaccines. Ann Intern Med. 1988; 109:383-8.
35. Hayden FG, Cote KM, Douglas RG Jr. Plaque inhibition assay for drug susceptibility testing of influenza viruses. Antimicrob Agents Chemother. 1980; 17:865-70. [IDIS 210500] [PubMed 7396473]
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37. Hall CB, Dolin R, Gala CL et al. Children with influenza A infection: treatment with rimantadine. Pediatrics. 1987; 80:275-82. [IDIS 233097] [PubMed 3302925]
38. Centers for Disease Control and Prevention. Isolation of avian influenza A (H5N1) viruses from humans—Hong Kong, May–December 1997. MMWR Morb Mortal Wkly Rep. 1997; 46:1204-7. [PubMed 9414153]
39. Hayden FG. Antivirals for pandemic influenza. J Infect Dis. 1997; 176(Suppl 1):S56-61.
40. Wintermeyer SM, Nahata MC. Rimantadine: a clinical perspective. Ann Pharmacother. 1995; 29:299-310. [IDIS 344895] [PubMed 7606077]
41. Kimberlin DW, Whitley RJ. Antiviral resistance: mechanisms, clinical significance, and future implications. J Antimicrob Chemother. 1996; 37:403-21. [IDIS 365650] [PubMed 9182098]
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43. Belshe RB, Hay AJ. Drug resistance and mechanisms of action on influenza A viruses. J Respir Dis. 1989; 10(Suppl):S52-61.
44. Englund JA, Champlin RE, Wyde PR et al. Common emergence of amantadine- and rimantadine-resistant influenza A viruses in symptomatic immunocompromised adults. Clin Infect Dis. 1998; 26:1418-24. [IDIS 409165] [PubMed 9636873]
45. Tilley JW, Kramer MJ. Aminoadamantane derivatives. Prog Med Chem. 1981; 18:1-44. [PubMed 7045980]
46. Hay AJ. The action of adamantanamines against influenza A viruses: inhibition of the M2 ion channel protein. Semin Virol. 1992; 3:21-30.
47. Monto AS, Ohmit SE, Hornbuckle K et al. Safety and efficacy of long-term use of rimantadine for prophylaxis of type A influenza in nursing homes. Antimicrob Agents Chemother. 1995; 39:2224-8. [IDIS 356007] [PubMed 8619572]
48. Houck P, Hemphill M, LaCroix S et al. Amantadine-resistant influenza A in nursing homes: identification of a resistant virus prior to drug use. Arch Intern Med. 1995; 155:533-7. [IDIS 344097] [PubMed 7864709]
49. Wills RJ, Farolino DA, Choma N et al. Rimantadine pharmacokinetics after single and multiple doses. Antimicrob Agents Chemother. 1987; 31:826-8. [IDIS 229471] [PubMed 3606083]
50. Nahata MC, Brady MT. Serum concentrations and safety of rimantadine in paediatric patients. Eur J Clin Pharmacol. 1986; 30:719-22. [IDIS 221616] [PubMed 3770065]
51. Hayden FG, Minocha A, Spyker DA et al. Comparative single-dose pharmacokinetics of amantadine hydrochloride and rimantadine hydrochloride in young and elderly adults. Antimicrob Agents Chemother. 1985; 28:216-21. [IDIS 204284] [PubMed 3834831]
52. Hayden FG, Minocha A, Spyker DA et al. Comparative single-dose pharmacokinetics of amantadine hydrochloride and rimantadine hydrochloride in young and elderly adults. Antimicrob Agents Chemother. 1985; 28:216-21. [IDIS 204284] [PubMed 3834831]
53. Patriarca PA, Kater NA, Kendal AP et al. Safety of prolonged administration of rimantadine hydrochloride in the prophylaxis of influenza A virus infections in nursing homes. Antimicrob Agents Chemother. 1984; 26:101-3. [IDIS 187634] [PubMed 6476812]
54. Tominack RL, Wills RJ, Gustavson LE et al. Multiple-dose pharmacokinetics of rimantadine in elderly adults. Antimicrob Agents Chemother. 1988; 32:1813-9. [IDIS 249129] [PubMed 3245694]
55. Rubio FR, Fukuda EK, Garland WA. Urinary metabolites of rimantadine in humans. Drug Metab Dispos. 1988; 16:773-7. [IDIS 246249] [PubMed 2906605]
56. Wills RJ, Choma N, Buonpane G et al. Relative bioavailability of rimantadine HCl tablet and syrup formulations in healthy subjects. J Pharm Sci. 1987; 76:886-8. [IDIS 236595] [PubMed 3440931]
57. Hay AJ, Zambon MC, Wolstenholme AJ et al. Molecular basis of resistance of influenza A viruses to amantadine. J Antimicrob Chemother. 1986; 18(Suppl B):19-29. [PubMed 3793659]
58. Clover RD, Waner JL, Becker L et al. Effect of rimantadine on the immune response to influenza A infections. J Med Virol. 1991; 34:68-73. [PubMed 1885945]
59. Thompson J, Fleet W, Lawrence E et al. A comparison of acetaminophen and rimantadine in the treatment of influenza A infection in children. J Med Virol. 1987; 21:249-55. [PubMed 3549971]
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61. Evans KD, Kline MW. Prolonged influenza A infection responsive to rimantadine therapy in a human immunodeficiency virus-infected child. Pediatr Infect Dis J. 1995; 14:332-4. [IDIS 345882] [PubMed 7603824]
62. Holazo AA, Choma N, Brown SY et al. Effect of cimetidine on the disposition of rimantadine in healthy subjects. Antimicrob Agents Chemother. 1989; 33:820-3. [IDIS 255712] [PubMed 2764530]
63. Reviewers’ comments (personal observations).
64. Berkowitz CD. Treatment of acute amantadine toxicity with physostigmine. J Pediatr. 1979; 95:144-5. [PubMed 479999]
65. Forest, St. Louis, MO: Personal communication.
66. Glaxo Wellcome Inc. Relenza (zanamivir) for inhalation product information. Research Triangle Center, NC; 1999.
67. Houck P, Hemphill M, LaCroix S et al. Amantadine-resistant influenza A in nursing homes: identification of a resistant virus prior to drug use. Arch Intern Med. 1995; 155:533-7. [IDIS 344097] [PubMed 7864709]
68. Hayden FG, Sperber SJ, Belshe RB et al. Recovery of drug-resistant influenza A virus during therapeutic use of rimantadine. Antimicrob Agents Chemother. 1991; 35:1741-7. [IDIS 287974] [PubMed 1952841]
69. Balfour HH. Antiviral drugs. N Engl J Med. 1999; 340:1255-68. [IDIS 423356] [PubMed 10210711]
70. Calfee DP, Hayden FG. New approaches to influenza chemotherapy: neuraminidase inhibitors. Drugs. 1998; 56:537-53. [PubMed 9806102]
71. Hayden FG, Treanor JJ, Fritz RS et al. Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: randomized controlled trials for prevention and treatment. JAMA. 1999; 282:1240-6. [IDIS 434353] [PubMed 10517426]
73. Lumpkin MM. Food and Drug Administration. Dear healthcare provider letter regarding safe and appropriate use of influenza drugs. Rockville, MD; 2000 Jan 12. From FDA website.
74. Monto AS, Robinson DP, Herlocher ML et al. Zanamivir in the prevention of influenza among healthy adults: a randomized controlled trial. JAMA. 1999; 282:31-5. [IDIS 427990] [PubMed 10404908]
75. Hayden FG, Treanor JJ, Fritz RS et al. Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: randomized controlled trials for prevention and treatment. JAMA. 1999; 282:1240-6. [IDIS 434353] [PubMed 10517426]
76. Centers for Disease Control and Prevention. Update: influenza activity—United States and worldwide, 2003-2004 season, and composition of the 2004-05 influenza vaccine. MMWR Morb Mortal Wkly Rep. 2004; 53:547-52. [PubMed 15229411]
77. US Centers for Disease Control and Prevention. Health information for international travel, 2010. Atlanta, GA: US Department of Health and Human Services; 2010. Updates available from CDC website.
78. Hayden FG. Antivirals for pandemic influenza. J Infect Dis. 1997; 176(Suppl 1):S56-61.
79. World Health Organization. WHO guidelines on the use of vaccines and antivirals during influenza pandemics. Geneva; WHO. 2004.
81. Nuzzo J. Federal advisory groups recommend priorities for vaccination and antivirals during a pandemic. CBN Weekly Bulletin. 2005 Aug 2.
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Arretin may be available in the countries listed below.
Tretinoin is reported as an ingredient of Arretin in the following countries:
International Drug Name Search
Solvex may be available in the countries listed below.
Bromhexine hydrochloride (a derivative of Bromhexine) is reported as an ingredient of Solvex in the following countries:
Reboxetine mesilate (a derivative of Reboxetine) is reported as an ingredient of Solvex in the following countries:
International Drug Name Search
In some countries, this medicine may only be approved for veterinary use.
USAN
D10AE01
0000094-36-0
C14-H10-O4
242
Disinfectant
Dermatological agent: Keratolytic
Dermatological agent: Topical antiseptic
Antiacne agent
Dibenzoyl peroxide (Ph. Int.)
Diphenylperoxyanhydride (IUPAC)
International Drug Name Search
Glossary
| IUPAC | International Union of Pure and Applied Chemistry |
| IS | Inofficial Synonym |
| OS | Official Synonym |
| PH | Pharmacopoeia Name |
| Ph. Int. | Pharmacopoea Internationalis |
| USAN | United States Adopted Name |
Mixtard 40 may be available in the countries listed below.
Insulin Injection, Biphasic Isophane is reported as an ingredient of Mixtard 40 in the following countries:
Insulin Injection, Biphasic Isophane human (a derivative of Insulin Injection, Biphasic Isophane) is reported as an ingredient of Mixtard 40 in the following countries:
International Drug Name Search
Motilium lingual may be available in the countries listed below.
Domperidone is reported as an ingredient of Motilium lingual in the following countries:
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Clotrimazol Al may be available in the countries listed below.
Clotrimazole is reported as an ingredient of Clotrimazol Al in the following countries:
Sulfamethoxazole is reported as an ingredient of Clotrimazol Al in the following countries:
Trimethoprim is reported as an ingredient of Clotrimazol Al in the following countries:
International Drug Name Search
In the US, Infadrops is a member of the drug class miscellaneous analgesics and is used to treat Fever, Muscle Pain, Pain and Sciatica.
Paracetamol is reported as an ingredient of Infadrops in the following countries:
International Drug Name Search
Moxifloxacin Hydrochloride may be available in the countries listed below.
Moxifloxacin Hydrochloride (USAN) is known as Moxifloxacin in the US.
International Drug Name Search
Glossary
| USAN | United States Adopted Name |
Maniprex may be available in the countries listed below.
Lithium carbonate (a derivative of Lithium) is reported as an ingredient of Maniprex in the following countries:
International Drug Name Search
Ceneo may be available in the countries listed below.
Hydrocortisone 17α-butyrate 21-propionate (a derivative of Hydrocortisone) is reported as an ingredient of Ceneo in the following countries:
International Drug Name Search
Metoclopramide Cloridrato may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Metoclopramide hydrochloride (a derivative of Metoclopramide) is reported as an ingredient of Metoclopramide Cloridrato in the following countries:
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Visol may be available in the countries listed below.
Tetryzoline hydrochloride (a derivative of Tetryzoline) is reported as an ingredient of Visol in the following countries:
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CO Topiramate may be available in the countries listed below.
Topiramate is reported as an ingredient of CO Topiramate in the following countries:
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Sandoz Zopiclone may be available in the countries listed below.
Zopiclone is reported as an ingredient of Sandoz Zopiclone in the following countries:
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Letrozol Teva may be available in the countries listed below.
Letrozole is reported as an ingredient of Letrozol Teva in the following countries:
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Nuctalon may be available in the countries listed below.
Estazolam is reported as an ingredient of Nuctalon in the following countries:
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Mevalect may be available in the countries listed below.
Pravastatin sodium salt (a derivative of Pravastatin) is reported as an ingredient of Mevalect in the following countries:
International Drug Name Search
Gardal may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Albendazole is reported as an ingredient of Gardal in the following countries:
Albendazole oxide (a derivative of Albendazole) is reported as an ingredient of Gardal in the following countries:
International Drug Name Search
Citrate de Bétaïne ratiopharm Conseil may be available in the countries listed below.
Betaine citrate (a derivative of Betaine) is reported as an ingredient of Citrate de Bétaïne ratiopharm Conseil in the following countries:
International Drug Name Search
Antagel PCH may be available in the countries listed below.
Aluminium Hydroxide hydrate (Algeldrate) (a derivative of Aluminium Hydroxide) is reported as an ingredient of Antagel PCH in the following countries:
Magnesium Hydroxide is reported as an ingredient of Antagel PCH in the following countries:
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Pravabasic may be available in the countries listed below.
Pravastatin sodium salt (a derivative of Pravastatin) is reported as an ingredient of Pravabasic in the following countries:
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Noradrenaline may be available in the countries listed below.
UK matches:
Noradrenaline (BAN) is known as Norepinephrine in the US.
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Glossary
| BAN | British Approved Name |
| SPC | Summary of Product Characteristics (UK) |
0025447-66-9
C32-H43-N5-O5
577
Vasodilator
9,10α-Dihydro-12'-hydroxy-5'α-isobutyl-2'-isopropylergotaman-3',6',18-trione
International Drug Name Search
Glossary
| DCF | Dénomination Commune Française |
| IS | Inofficial Synonym |
| OS | Official Synonym |
Trogas may be available in the countries listed below.
Lansoprazole is reported as an ingredient of Trogas in the following countries:
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Drill Pastillas may be available in the countries listed below.
Benzocaine is reported as an ingredient of Drill Pastillas in the following countries:
Chlorhexidine digluconate (a derivative of Chlorhexidine) is reported as an ingredient of Drill Pastillas in the following countries:
International Drug Name Search
Liquid SeeVitE may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Selenium is reported as an ingredient of Liquid SeeVitE in the following countries:
Tocopherol, α- is reported as an ingredient of Liquid SeeVitE in the following countries:
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Sinamox may be available in the countries listed below.
Amoxicillin trihydrate (a derivative of Amoxicillin) is reported as an ingredient of Sinamox in the following countries:
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Povidone iodée Merck may be available in the countries listed below.
Povidone-Iodine is reported as an ingredient of Povidone iodée Merck in the following countries:
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Generic Name: aspirin and oxycodone (AS pir in and ox i KOE done)
Brand Names: Endodan, Percodan, Roxiprin
Aspirin is in a group of drugs called salicylates (sa-LIS-il-ates). It works by reducing substances in the body that cause pain, fever, and inflammation.
Oxycodone is in a group of drugs called narcotic pain relievers.
The combination of aspirin and oxycodone is used to relieve moderate to severe pain.
Aspirin and oxycodone may also be used for purposes not listed in this medication guide.
Stop using this medication and call your doctor at once if you have any symptoms of bleeding in your stomach or intestines. Symptoms include black, bloody, or tarry stools, and coughing up blood or vomit that looks like coffee grounds.
Tell your doctor if the medicine seems to stop working as well in relieving your pain.
To make sure you can safely take this medicine, tell your doctor if you have any of these other conditions:
asthma or other breathing disorders;
a history of head injury or brain tumor;
epilepsy or other seizure disorder;
stomach or intestinal disorder, history of stomach ulcer or bleeding;
a pancreas disorder;
curvature of the spine; or
mental illness or a history of drug or alcohol addiction.
Older adults may be more sensitive to the effects of this medicine.
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.
Keep track of the amount of medicine used from each new bottle. Oxycodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
Always check your bottle to make sure you have received the correct pills (same brand and type) of medicine prescribed by your doctor. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy.
After you have stopped using this medication, flush any unused pills down the toilet.
Since aspirin and oxycodone is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Overdose symptoms may include extreme drowsiness, pinpoint pupils, nausea, vomiting, diarrhea, confusion, ringing in your ears, cold or clammy skin, muscle weakness, fainting, weak pulse, slow heart rate, coma, blue lips, shallow breathing, or no breathing.
black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee ground;
shallow breathing, slow heartbeat;
fast heart rate;
feeling light-headed, fainting;
confusion, hallucinations;
easy bruising or bleeding; or
problems with urination.
Less serious side effects may include:
headache, dizziness, drowsiness;
heartburn, nausea, vomiting, upset stomach, bloating, gas, constipation, diarrhea;
feeling dizzy or drowsy;
headache;
sweating;
ringing in your ears; or
dry mouth.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor about all other medicines you use, especially:
acetazolamide (Diamox);
a diuretic (water pill);
methotrexate (Rheumatrex, Trexall);
steroids (prednisone and others);
a blood thinner such as warfarin (Coumadin, Jantoven);
a bronchodilator (such as Atrovent, Spiriva);
atropine (Donnatal), dimenhydrinate (Dramamine), or scopolamine (Transderm-Scop);
insulin or diabetes medications that you take by mouth;
an ACE inhibitor such as benazepril (Lotensin), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and others;
a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;
bowel or bladder medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin), tolterodine (Detrol) and others; or
an NSAID such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Celecoxib, Voltaren), etodolac (Lodine), indomethacin (Indocin), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others.
This list is not complete and other drugs may interact with aspirin and oxycodone. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
See also: Roxiprin side effects (in more detail)
