Topamax

Pronunciation: toe-PIR-a-mate
Generic Name: Topiramate
Brand Name: Topamax

Topamax is used for:

Treating seizures in certain patients. It may be used alone or with other medicines. It is also used to prevent migraine headaches. It may also be used for other conditions as determined by your doctor.

Topamax is an anticonvulsant that is also effective for preventing migraine headaches. It works by affecting several chemicals in the brain that help to reduce seizure activity and prevent migraine headaches from occurring.

Do NOT use Topamax if:

• you are allergic to any ingredient in Topamax


• you are taking a carbonic anhydrase inhibitor (eg, acetazolamide)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Topamax:

Some medical conditions may interact with Topamax. Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you may become pregnant


• if you have eye problems (eg, glaucoma), liver or kidney problems, kidney stones, or osteoporosis (weak bones) or soft bones; you drink alcohol regularly; you are on a ketogenic diet; or you are receiving kidney dialysis


• if you have diarrhea, lung or breathing problems, low bicarbonate levels in the blood, or a growth problem, or you will be having surgery


• if you have a history of status epilepticus (continuous seizure activity or a series of seizures without a full return to consciousness) or high blood acid levels (metabolic acidosis)


• if you have a history of mental or mood problems (eg, depression), or suicidal thoughts or actions


• if you take any other medicine for seizures

Some MEDICINES MAY INTERACT with Topamax. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticholinergics (eg, benztropine), carbonic anhydrase inhibitors (eg, acetazolamide), haloperidol, or tricyclic antidepressants (eg, nortriptyline) because the risk of decreased sweating may be increased


• Valproic acid because a serious side effect with symptoms of confusion, lethargy, and vomiting may occur


• Metformin or pioglitazone because blood glucose control may be altered; monitor your blood sugar carefully if you use Topamax with metformin or pioglitazone


• Hydrochlorothiazide because it may increase the risk of Topamax's side effects


• Carbamazepine or hydantoins (eg, phenytoin) because they may decrease Topamax's effectiveness


• Amitriptyline because the risk of its side effects may be increased by Topamax


• Lithium because Topamax may have an effect on lithium blood levels


• Hormonal birth control (eg, birth control pills) or risperidone because their effectiveness may be decreased by Topamax

This may not be a complete list of all interactions that may occur. Ask your health care provider if Topamax may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Topamax:

Use Topamax as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Topamax comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Topamax refilled.


• Take Topamax by mouth with or without food.


• Drink plenty of fluids while taking Topamax to prevent kidney stones from forming.


• Swallow Topamax whole. Do not crush, break, or chew before swallowing.


• Do not suddenly stop taking Topamax. Suddenly stopping Topamax may cause seizures to occur more often. If you need to stop Topamax, your doctor will gradually lower your dose.


• If you miss a dose of Topamax, take it as soon as possible. If it is within 6 hours of your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Contact your doctor if you miss more than 1 dose of Topamax.

Ask your health care provider any questions you may have about how to use Topamax.

Important safety information:

• Topamax may cause drowsiness, dizziness, confusion, or trouble concentrating. These effects may be worse if you take it with alcohol or certain medicines. Use Topamax with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not change your dose without checking with your doctor.


• Do not drink alcohol while you take Topamax.


• Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are taking Topamax; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Topamax may reduce sweating, which could raise body temperature, especially in children. This risk is greater in hot weather and/or during vigorous exercise. Drink plenty of fluids. Dress lightly in hot climates or when exercising. Check carefully for signs of decreased sweating. If this occurs, promptly seek cooler or air-conditioned shelter and/or stop exercising. Seek medical attention right away if you have unexplained fever, mental or mood changes, headache, or dizziness.


• Topamax may cause high blood acid levels (metabolic acidosis). The risk may be greater in children and patients with kidney problems, severe breathing problems, or diarrhea. It may also be greater in patients who are taking certain other medicines (eg, acetazolamide), will be having surgery, or are on a ketogenic diet. Over a period of time, metabolic acidosis may cause kidney problems, bone problems, or decreased growth in children. Contact your doctor immediately if you experience fast breathing, unusual weakness or fatigue, sluggishness, persistent loss of appetite, or irregular heartbeat.


• Patients who take Topamax may be at increased risk of suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Watch patients who take Topamax closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.


• Topamax may cause serious eye problems that could lead to permanent loss of vision if not treated. Seek medical attention right away if you experience new eye symptoms (eg, blurred vision or other vision changes, eye pain or redness).


• Tell your doctor or dentist that you take Topamax before you receive any medical or dental care, emergency care, or surgery.


• Hormonal birth control (eg, birth control pills) may not work as well while you are using Topamax. To prevent pregnancy, use an extra form of birth control (eg, condoms). Discuss any questions or concerns with your doctor.


• Lab tests, including serum bicarbonate levels, may be performed while you use Topamax. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Topamax with caution in the ELDERLY; they may be more sensitive to its effects.


• Caution is advised when using Topamax in CHILDREN; they may be more sensitive to its effects, especially decreased sweating and decreased bicarbonate levels.


• Topamax may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they take Topamax.


• Topamax should be used with extreme caution in CHILDREN for migraines and in CHILDREN younger than 2 years for seizures; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Topamax may cause birth defects if you take it while you are pregnant. Avoid becoming pregnant by using an effective form of birth control while you are taking Topamax. If you think you may be pregnant or you are planning to become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Topamax while you are pregnant. Topamax is found in breast milk. If you are or will be breast-feeding while you take Topamax, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Topamax:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; decreased sweating; diarrhea; dizziness; drowsiness; dry mouth; flu-like symptoms; headache; loss of appetite; nausea; nervousness; numbness or tingling of the skin; runny nose; sore throat; stomach pain or upset; taste changes; tiredness; trouble sleeping; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; blurred vision; bone pain; chest pain; confusion; decreased coordination; double vision or other vision changes; eye pain or redness; irregular heartbeat; loss of consciousness; memory problems; menstrual changes; muscle or joint pain, cramps, or weakness; new or worsening mental or mood changes (eg, aggressiveness, agitation, anxiety, depression, exaggerated feeling of well-being, hostility, impulsiveness, inability to sit still, irritability, panic attacks, restlessness); rapid, shallow breathing; red, swollen, blistered, or peeling skin; ringing in the ears; severe or persistent loss of appetite; severe stomach, side, or back pain; significant weight loss; speech problems; stupor; suicidal thoughts or actions; tremor; trouble thinking, concentrating, or remembering things; trouble walking; unexplained fever; unusual bruising or bleeding; unusual eye movements; unusual tiredness; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Topamax side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; depression; fainting; loss of coordination; mental impairment; seizures; severe drowsiness or dizziness; severe or persistent stomach pain; sluggishness; speech problems; stupor; vision problems (eg, blurred or double vision).

Proper storage of Topamax:

Store Topamax at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, light, and moisture. Do not store in the bathroom. Keep Topamax out of the reach of children and away from pets.

General information:

• If you have any questions about Topamax, please talk with your doctor, pharmacist, or other health care provider.


• Topamax is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Topamax. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Topamax resources

• Topamax Side Effects (in more detail)
• Topamax Use in Pregnancy & Breastfeeding
• Drug Images
• Topamax Drug Interactions
• Topamax Support Group
• 188 Reviews for Topamax - Add your own review/rating

• Topamax Prescribing Information (FDA)


• Topamax Consumer Overview


• Topamax Monograph (AHFS DI)


• Topamax Advanced Consumer (Micromedex) - Includes Dosage Information


• Topiramate Prescribing Information (FDA)


• Topiramate Professional Patient Advice (Wolters Kluwer)


• Topiragen Prescribing Information (FDA)

Compare Topamax with other medications

• Bipolar Disorder
• Bulimia
• Crohn's Disease
• Diabetic Nerve Damage
• Fibromyalgia
• Migraine Prevention
• Obesity
• Seizure Prevention
• Smoking Cessation
• Tourette's Syndrome
• Trigeminal Neuralgia
• Vulvodynia

Tinaderm Topical

Generic Name: tolnaftate (Topical route)

tol-NAF-tate

Commonly used brand name(s)

In the U.S.

• Absorbine Jr. Antifungal


• Aftate


• Blis-To-Sol


• Dermasept Antifungal


• Fungi-Guard


• Podactin


• Q-Naftate


• Tinactin


• Tinaderm


• Ting

In Canada

• Athlete's Foot Gel


• Dr. Scholl's Athlete's Foot


• Pitrex


• Scholl's Athlete's Foot Spray


• Scholl Tritin Antifungal Powder


• Scholl Tritin Antifungal Spray Powder


• Tinactin Aerosol Liquid


• Tinactin Aerosol Powder


• Tinactin Jock Itch


• Tinactin Plus


• Tinactin Plus Aerosol Powder

Available Dosage Forms:

• Ointment


• Spray


• Cream


• Lotion


• Gel/Jelly


• Powder


• Solution

Therapeutic Class: Antifungal

Uses For Tinaderm

Tolnaftate belongs to the group of medicines called antifungals. It is used to treat some types of fungus infections. It may also be used together with medicines taken by mouth for fungus infections.

Tolnaftate is available without a prescription.

Before Using Tinaderm

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Tolnaftate should not be used on children up to 2 years of age, unless otherwise directed by your doctor. Although there is no specific information comparing use of tolnaftate in children 2 years of age and older with use in other age groups, this medicine is not expected to cause different side effects or problems in children 2 years of age and older than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of tolnaftate in the elderly with use in other age groups.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of tolnaftate

This section provides information on the proper use of a number of products that contain tolnaftate. It may not be specific to Tinaderm. Please read with care.

Before applying tolnaftate, wash the affected area and dry thoroughly. Then apply enough medicine to cover the affected area.

Keep this medicine away from the eyes.

For patients using the powder form of this medicine:

• If the powder is used on the feet, sprinkle it between toes, on feet, and in socks and shoes.

For patients using the aerosol powder form of this medicine:

• Shake well before using.


• From a distance of 6 to 10 inches, spray the powder on the affected areas. If it is used on the feet, spray it between toes, on feet, and in socks and shoes.


• Do not inhale the powder.


• Do not use near heat, near open flame, or while smoking.

For patients using the solution form of this medicine:

• If tolnaftate solution becomes a solid, it may be dissolved by warming the closed container of medicine in warm water.

For patients using the aerosol solution form of this medicine:

• Shake well before using.


• From a distance of 6 inches, spray the solution on the affected areas. If it is used on the feet, spray between toes and on feet.


• Do not inhale the vapors from the spray.


• Do not use near heat, near open flame, or while smoking.

To help clear up your infection completely, keep using this medicine for 2 weeks after burning, itching, or other symptoms have disappeared , unless otherwise directed by your doctor. Do not miss any doses.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For topical dosage forms (aerosol powder, aerosol solution, cream, gel, powder, or topical solution):
  
  • For fungus infections:
    
    • Adults and children 2 years of age and over—Apply to the affected area(s) of the skin two times a day.
    
    
    • Children up to 2 years of age—Use is not recommended except under the advice and supervision of your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the canister at room temperature, away from heat and direct light. Do not freeze. Do not keep this medicine inside a car where it could be exposed to extreme heat or cold. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Tinaderm

If your skin problem does not improve within 4 weeks, or if it becomes worse, check with your health care professional.

To help prevent reinfection after the period of treatment with this medicine, the powder or spray powder form of this medicine may be used each day after bathing and carefully drying the affected area.

Tinaderm Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• Skin irritation not present before use of this medicine

When you apply the aerosol solution form of this medicine, a mild temporary stinging may be expected.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Tinaderm Topical side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Tinaderm Topical resources

• Tinaderm Topical Side Effects (in more detail)
• Tinaderm Topical Use in Pregnancy & Breastfeeding
• Tinaderm Topical Support Group
• 0 Reviews for Tinaderm Topical - Add your own review/rating

Compare Tinaderm Topical with other medications

• Tinea Corporis
• Tinea Cruris
• Tinea Pedis
• Tinea Versicolor

Methylin

Pronunciation: METH-il-FEN-i-date
Generic Name: Methylphenidate
Brand Name: Examples include Methylin and Ritalin

Use Methylin with caution if you have a history of emotional problems, or alcohol or substance abuse. Abuse of Methylin may cause it to not work as well. Abuse may also lead to addiction and severe mental changes. Do not suddenly stop using Methylin. Depression and other mental problems may occur. Your doctor should slowly lower your dose over a period of time if you need to stop using it.

Methylin is used for:

Treating attention deficit disorder (ADD). It is also used to treat uncontrollable periods of daytime sleep (narcolepsy). It may also be used for other conditions as determined by your doctor.

Methylin is a central nervous system stimulant. Exactly how it works is not known.

Do NOT use Methylin if:

• you are allergic to any ingredient in Methylin


• you have severe anxiety, agitation, or tension


• you have glaucoma


• you have motor tics (involuntary movements), Tourette syndrome, or a family history of Tourette syndrome


• you have serious heart problems (eg, heart defect, irregular heartbeat)


• you are taking a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) or have taken an MAOI within the past 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Methylin:

Some medical conditions may interact with Methylin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of high blood pressure, heart problems (eg, heart failure, fast or irregular heartbeat), or a recent heart attack, or if a family member has a history of irregular heartbeat or sudden death


• if you have a history of seizures or abnormal electroencephalograms (EEGs)


• if you have a history of overactive thyroid, chronic fatigue, cystic fibrosis, or stomach or bowel problems (eg, blockage, inflammation, narrowing)


• if you have a history of mood or mental problems (eg, agitation, anxiety, bipolar disorder, depression, psychosis, tension), abnormal thoughts, hallucinations, suicidal thoughts or attempts, or alcohol or other substance abuse or dependence, or if a family member has a history of any of these problems

Some MEDICINES MAY INTERACT with Methylin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• MAOIs (eg, phenelzine) because severe high blood pressure may occur


• Clonidine because serious side effects may occur


• Anticoagulants (eg, warfarin), certain anticonvulsants (eg, phenobarbital, phenytoin, primidone), phenylbutazone, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), or tricyclic antidepressants (eg, imipramine) because the risk of their side effects may be increased by Methylin


• Medicines for high blood pressure (eg, guanethidine, metoprolol) because their effectiveness may be decreased by Methylin

This may not be a complete list of all interactions that may occur. Ask your health care provider if Methylin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Methylin:

Use Methylin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Methylin comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Methylin refilled.


• Take Methylin by mouth 30 to 45 minutes before eating unless your doctor tells you otherwise.


• You may have trouble sleeping while taking Methylin. If this occurs, taking your last dose before 6 pm may help. Check with your doctor before you change the way that you take Methylin. If trouble sleeping continues, talk with your doctor.


• If you miss a dose of Methylin, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Methylin.

Important safety information:

• Methylin may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Methylin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do NOT take more than the recommended dose without checking with your doctor.


• If your symptoms do not get better within 1 month or if they get worse, check with your doctor.


• Serious effects, including heart attack, stroke, and sudden death, have occurred with the use of stimulant medicines in patients with heart defects or other serious heart problems. If you have a heart defect or another serious problem, talk with your doctor about other therapies to treat your condition.


• Tell your doctor or dentist that you take Methylin before you receive any medical or dental care, emergency care, or surgery.


• Lab tests, including blood pressure, heart function, complete blood cell counts, and platelet counts, may be performed while you use Methylin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Methylin may affect growth rate and weight gain in CHILDREN and teenagers in some cases. They may need regular growth and weight checks while they take Methylin.


• Caution is advised when using Methylin in CHILDREN; they may be more sensitive to its effects, especially loss of appetite, stomach pain, weight loss, trouble sleeping, and fast heartbeat.


• Methylin should not be used in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Methylin while you are pregnant. It is not known if Methylin is found in breast milk. If you are or will be breast-feeding while you use Methylin, check with your doctor. Discuss any possible risks to your baby.

When used for long periods of time or at high doses, Methylin may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Methylin stops working well. Do not take more than prescribed.

Some people who use Methylin for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. Do not suddenly stop taking Methylin. If you do, you may have WITHDRAWAL symptoms. These may include depression or other mental problems. If you need to stop Methylin, your doctor will lower your dose over time.

Possible side effects of Methylin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; headache; loss of appetite; nausea; nervousness; stomach pain; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; joint pain; purple or brownish red spots on the skin); behavior changes (eg, aggression, hostility, restlessness); blurred vision or other vision problems; chest pain; confusion; dark urine; fainting; fast or irregular heartbeat; fever, chills, or sore throat; hallucinations; mental or mood changes (eg, agitation, anxiety, depression, irritability, panic attacks, persistent crying, unusual sadness); one-sided weakness; seizures; severe or persistent dizziness or headache; shortness of breath; slurred speech; suicidal thoughts or attempts; tremor; uncontrolled speech or muscle movements; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Methylin side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; dilated pupils; fast or irregular heartbeat; fever; flushing; hallucinations; loss of consciousness; muscle twitching; seizures; severe or persistent headache; tremors; unusual sweating; vomiting.

Proper storage of Methylin:

Store Methylin at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Methylin out of the reach of children and away from pets.

General information:

• If you have any questions about Methylin, please talk with your doctor, pharmacist, or other health care provider.


• Methylin is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Methylin. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Methylin resources

• Methylin Side Effects (in more detail)
• Methylin Dosage
• Methylin Use in Pregnancy & Breastfeeding
• Drug Images
• Methylin Drug Interactions
• Methylin Support Group
• 13 Reviews for Methylin - Add your own review/rating

• Methylin Advanced Consumer (Micromedex) - Includes Dosage Information


• Methylin Prescribing Information (FDA)


• Concerta Consumer Overview


• Concerta Prescribing Information (FDA)


• Daytrana Consumer Overview


• Daytrana Prescribing Information (FDA)


• Metadate CD Prescribing Information (FDA)


• Metadate ER Prescribing Information (FDA)


• Methylphenidate Hydrochloride Monograph (AHFS DI)


• Ritalin Prescribing Information (FDA)


• Ritalin Consumer Overview


• Ritalin LA Prescribing Information (FDA)

Compare Methylin with other medications

• ADHD
• Narcolepsy

Fluolar Mild

Generic Name: fluocinolone (Topical application route)

floo-oh-SIN-oh-lone a-SEET-oh-nide

Commonly used brand name(s)

In the U.S.

• Capex


• Derma-Smoothe/FS


• Synalar

In Canada

• Fluoderm Mild Cream


• Fluoderm Mild Ointment


• Fluoderm Regular Cream


• Fluoderm Regular Ointment


• Fluolar Mild


• Fluolar Regular


• Fluonide Mild-Cream


• Synalar Mild


• Synalar Regular


• Synamol

Available Dosage Forms:

• Cream


• Solution


• Shampoo


• Oil


• Ointment


• Lotion


• Gel/Jelly


• Kit

Therapeutic Class: Corticosteroid, Intermediate

Pharmacologic Class: Fluocinolone

Uses For Fluolar Mild

Fluocinolone topical is used to relieve redness, itching, swelling, or other discomfort caused by skin conditions. Fluocinolone scalp oil is used to treat psoriasis of the scalp, and fluocinolone shampoo for seborrheic dermatitis of the scalp. This medicine is a corticosteroid (cortisone-like medicine or steroid).

This medicine is available only with your doctor's prescription.

Before Using Fluolar Mild

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of fluocinolone topical in the pediatric population. However, because of this medicine's toxicity, it should be used with caution. Children may absorb large amounts through the skin, which can cause serious side effects. If your child is using this medicine, follow your doctor's instructions very carefully. For the body oil form, safety and efficacy in children 3 months of age and younger have not been established.

Geriatric

No information is available on the relationship of age to the effects of fluocinolone topical in geriatric patients.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Cushing's syndrome (adrenal gland disorder) or


• Diabetes or


• Hyperglycemia (high blood sugar) or


• Intracranial hypertension (increased pressure in the head)—Use with caution. May make these conditions worse.

• Infection of the skin at or near the place of application or


• Large sores, broken skin, or severe skin injury at the place of application—The chance of side effects may be increased.

Proper Use of fluocinolone

This section provides information on the proper use of a number of products that contain fluocinolone. It may not be specific to Fluolar Mild. Please read with care.

It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects or skin irritation.

This medicine is for use on the skin only. Do not get it in your eyes. Do not use it on skin areas that have cuts, scrapes, or burns. If it does get on these areas, rinse it off right away with water.

This medicine should only be used for skin conditions that your doctor is treating. Check with your doctor before using it for other conditions, especially if you think that a skin infection may be present. This medicine should not be used to treat certain kinds of skin infections or conditions, such as severe burns.

To use cream, ointment, solution, and body oil:

• Wash your hands with soap and water before and after using this medicine.


• Apply a thin layer of this medicine to the affected area of the skin or scalp. Rub it in gently.


• Do not bandage or otherwise wrap the skin being treated unless directed to do so by your doctor.


• If the medicine is applied to the diaper area of an infant, do not use tight-fitting diapers or plastic pants unless directed to do so by your doctor.


• If your doctor ordered an occlusive dressing or airtight covering to be applied over the medicine, make sure you know how to apply it. Occlusive dressings increase the amount of medicine absorbed through your skin, so use them only as directed. If you have any questions about this, check with your doctor.

To use shampoo:

• Wash your hands with soap and water before and after using this medicine.


• Wet hair and scalp thoroughly.


• Shake the container well, and apply about an ounce of the shampoo to the scalp area.


• Work the shampoo into a lather, and leave on the scalp for 5 minutes.


• Wash hair and scalp thoroughly with water.

To use scalp oil:

• Wash your hands with soap and water before and after using this medicine.


• Wet hair and scalp thoroughly.


• Apply a thin layer of this medicine to the affected area of the scalp. Rub it in gently.


• Cover the scalp with the supplied shower cap overnight for at least 4 hours.


• Wash hair with regular shampoo and clean well.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For redness, itching, and swelling of the skin:
  
  • For topical dosage form (cream, ointment, and solution):
    
    • Adults—Apply to the affected areas of the skin three to four times a day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For topical dosage form (body oil):
    
    • Adults—Apply to the affected areas of the skin three times a day for up to 2 weeks.
    
    
    • Children 3 months of age and older—Apply to the affected areas two times a day for up to 4 weeks.
    
    
  
  

• For seborrheic dermatitis:
  
  • For topical dosage form (shampoo):
    
    • Adults—Use on the scalp area once a day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

• For scalp psoriasis:
  
  • For topical dosage form (scalp oil):
    
    • Adults—Apply to the affected areas of the scalp and leave overnight.
    
    
    • Children 2 years of age and older—Apply to the affected areas 2 times a day for up to 4 weeks.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Fluolar Mild

It is very important that your doctor check the progress of you or your child at regular visits for any unwanted effects that may be caused by this medicine.

If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.

Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. The risk is greater for children and patients who use large amounts for a long time. Talk to your doctor right away if you or your child have more than one of these symptoms while you are using this medicine: blurred vision; dizziness or fainting; a fast, irregular, or pounding heartbeat; increased thirst or urination; irritability; or unusual tiredness or weakness.

Stop using this medicine and check with your doctor right away if you or your child have a skin rash, burning, stinging, swelling, or irritation on the skin.

Fluolar Mild Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Body aches or pain


• congestion


• cough


• dryness or soreness of the throat


• fever


• headache


• hoarseness


• lightening of normal skin color


• lightening of treated areas of dark skin


• sore throat


• stuffy or runny nose


• tender, swollen glands in the neck


• trouble swallowing


• unusual tiredness or weakness


• voice changes

Less common

• Acne or pimples


• accumulation of pus


• blistering, crusting, irritation, itching, or reddening of the skin


• burning, itching, and pain in hairy areas, or pus at the root of the hair


• burning and itching of the skin with pinhead-sized red blisters


• change in hearing


• cracked, dry, scaly skin


• diarrhea


• dry skin


• earache or pain in the ear


• ear drainage


• flushing or redness of the skin


• darkening of the skin


• itching, scaling, severe redness, soreness, or swelling of the skin


• itchy, raised, round, smooth, skin-colored bumps found on just one area of the body


• ooze thick white fluid


• raised, dark red, wart-like spots on skin, especially when used on the face


• redness or swelling in the ear


• skin irritation


• skin rash, encrusted, scaly and oozing


• spots on your skin resembling a blister or pimple


• swelling


• swollen, red, tender area of infection


• thickened patches of the skin


• vomiting

Incidence not known

• Redness and scaling around the mouth


• thinning, weakness, or wasting away of the skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Changes in skin color


• shiny skin

Incidence not known

• increased hair growth on the forehead, back, arms, and legs


• reddish purple lines on the arms, face, legs, trunk, or groin


• softening of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Fluolar Mild resources

• Fluolar Mild Use in Pregnancy & Breastfeeding
• Fluolar Mild Drug Interactions
• Fluolar Mild Support Group
• 3 Reviews for Fluolar - Add your own review/rating

Compare Fluolar Mild with other medications

• Atopic Dermatitis
• Dermatitis
• Lichen Sclerosus

Intal

cromolyn sodium

Dosage Form: Inhalant

For Oral Inhalation Only

Rx only

Description

The active ingredient of Intal Inhaler is cromolyn sodium, USP. It is an inhaled anti-inflammatory agent for the preventive management of asthma. Cromolyn sodium is disodium 5, 5'-[(2-hydroxytrimethylene)dioxy]bis[4-oxo-4H-1-benzopyran-2-carboxylate]. The empirical formula is C23H14Na2O11; the molecular weight is 512.34. Cromolyn sodium is a water soluble, odorless, white, hydrated crystalline powder. It is tasteless at first, but leaves a slightly bitter aftertaste. The molecular structure of cromolyn sodium is:

Intal Inhaler (cromolyn sodium inhalation aerosol) is a metered dose aerosol unit for oral inhalation containing micronized cromolyn sodium, sorbitan trioleate with dichlorotetrafluoroethane and dichlorodifluoromethane as propellants. Each actuation delivers approximately 1 mg cromolyn sodium from the valve and 800 mcg cromolyn sodium through the mouthpiece to the patient. Each 8.1 g canister delivers at least 112 metered inhalations (56 doses); each 14.2 g canister delivers at least 200 metered inhalations (100 doses).

Clinical Pharmacology

In vitro and in vivo animal studies have shown that cromolyn sodium inhibits sensitized mast cell degranulation which occurs after exposure to specific antigens. Cromolyn sodium acts by inhibiting the release of mediators from mast cells. Studies show that cromolyn sodium indirectly blocks calcium ions from entering the mast cell, thereby preventing mediator release.

Cromolyn sodium inhibits both the immediate and non-immediate bronchoconstrictive reactions to inhaled antigen. Cromolyn sodium also attenuates bronchospasm caused by exercise, toluene diisocyanate, aspirin, cold air, sulfur dioxide, and environmental pollutants, at least in some patients.

Cromolyn sodium has no intrinsic bronchodilator or antihistamine activity.

After administration of cromolyn sodium capsules by inhalation, approximately 8% of the total dose administered is absorbed and rapidly excreted unchanged, approximately equally divided between urine and bile. The remainder of the dose is either exhaled or deposited in the oropharynx, swallowed, and excreted via the alimentary tract.

Indications and Usage

Intal Inhaler is a prophylactic agent indicated in the management of patients with bronchial asthma.

In patients whose symptoms are sufficiently frequent to require a continuous program of medication, Intal Inhaler is given by inhalation on a regular daily basis. (See DOSAGE AND ADMINISTRATION.) The effect of Intal Inhaler is usually evident after several weeks of treatment, although some patients show an almost immediate response.

If improvement occurs, it will ordinarily occur within the first 4 weeks of administration as manifested by a decrease in the severity of clinical symptoms of asthma, or in the need for concomitant therapy, or both.

In patients who develop acute bronchoconstriction in response to exposure to exercise, toluene diisocyanate, environmental pollutants, known antigens, etc., IntalInhaler should be used shortly before exposure to the precipitating factor, i.e., within 10 to 15 minutes but not more than 60 minutes. (See DOSAGE AND ADMINISTRATION.) Intal Inhaler may be effective in relieving bronchospasm in some, but not all, patients with exercise induced bronchospasm.

Contraindications

Intal Inhaler is contraindicated in those patients who have shown hypersensitivity to cromolyn sodium or other ingredients in this preparation.

Warnings

Intal Inhaler has no role in the treatment of an acute attack of asthma, especially status asthmaticus. Severe anaphylactic reactions can occur after cromolyn sodium administration. The recommended dosage should be decreased in patients with decreased renal or hepatic function. Intal Inhaler should be discontinued if the patient develops eosinophilic pneumonia (or pulmonary infiltrates with eosinophilia). Because of the propellants in this preparation, it should be used with caution in patients with coronary artery disease or a history of cardiac arrhythmias.

Precautions

General

In view of the biliary and renal routes of excretion for cromolyn sodium, consideration should be given to decreasing the dosage or discontinuing the administration of the drug in patients with impaired renal or hepatic function.

Occasionally, patients may experience cough and/or bronchospasm following cromolyn sodium inhalation. At times, patients who develop bronchospasm may not be able to continue administration despite prior bronchodilator administration. Rarely, very severe bronchospasm has been encountered.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long-term studies of cromolyn sodium in mice (12 months intraperitoneal administration at doses up to 150 mg/kg/day three days per week), hamsters (intraperitoneal administration at doses up to 53 mg/kg/day three days per week for 15 weeks followed by 17.5 mg/kg/day three days per week for 37 weeks), and rats (18 months subcutaneous treatment at doses up to 75 mg/kg/day six days per week) showed no neoplastic effects. These doses in mice, hamsters, and rats correspond to approximately 40, 10, and 80 times, respectively, the maximum recommended daily inhalation dose in adults on a mg/m2 basis, or, approximately 20, 5, and 40 times, respectively, the maximum recommended daily inhalation dose in children on a mg/m2 basis.

Cromolyn sodium showed no mutagenic potential in Ames Salmonella/microsome plate assays, mitotic gene conversion in Saccharomyces cerevisiae, and in an in vitro cytogenetic study in human peripheral lymphocytes.

No evidence of impaired fertility was shown in laboratory reproduction studies conducted subcutaneously in rats at the highest doses tested, 175 mg/kg/day in males and 100 mg/kg/day in females. These doses are approximately 220 and 130 times, respectively, the maximum recommended daily inhalation dose in adults on a mg/m2 basis.

Pregnancy

Pregnancy Category B: Reproduction studies with cromolyn sodium administered subcutaneously to pregnant mice and rats at maximum daily doses of 540 mg/kg/day and 160 mg/kg/day, respectively, and intravenously to rabbits at a maximum daily dose of 485 mg/kg/day produced no evidence of fetal malformations. These doses represent approximately 340, 210, and 1,200 times, respectively, the maximum recommended daily inhalation dose in adults on a mg/m2 basis. Adverse fetal effects (increased resorption and decreased fetal weight) were noted only at the very high parenteral doses that produced maternal toxicity. There are, however, no adequate and well-controlled studies in pregnant women.

Because animal reproduction studies are not always predictive of human response, Intal Inhaler should be used during pregnancy only if clearly needed.

Drug Interactions During Pregnancy

Cromolyn sodium and isoproterenol were studied following subcutaneous injections in pregnant mice. Cromolyn sodium alone in doses up to 540 mg/kg/day (approximately 340 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) did not cause significant increases in resorptions or major malformations. Isoproterenol alone at a dose of 2.7 mg/kg/day (approximately 7 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) increased both resorptions and malformations. The addition of 540 mg/kg/day of cromolyn sodium (approximately 340 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) to 2.7 mg/kg/day of isoproterenol (approximately 7 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) appears to have increased the incidence of both resorptions and malformations.

Nursing Mothers

It is not known whether this drug is excreted in human milk, therefore, caution should be exercised when Intal Inhaler is administered to a nursing woman and the attending physician must make a benefit/risk assessment in regard to its use in this situation.

Pediatric Use

Safety and effectiveness in pediatric patients below the age of 5 years have not been established. For young pediatric patients unable to utilize the Inhaler, Intal Nebulizer Solution (cromolyn sodium inhalation solution, USP) is recommended. Because of the possibility that adverse effects of this drug could become apparent only after many years, a benefit/risk consideration of the long-term use of Intal Inhaler is particularly important in pediatric patients.

Geriatric Use

Clinical studies of Intal Inhaler did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients.

Adverse Reactions

In controlled clinical studies of Intal Inhaler, the most frequently reported adverse reactions attributed to cromolyn sodium treatment were:

	Throat irritation or dryness
	Bad taste
	Cough
	Wheeze
	Nausea

The most frequently reported adverse reactions attributed to other forms of cromolyn sodium (on the basis of reoccurrence following readministration) involve the respiratory tract and are: bronchospasm [sometimes severe, associated with a precipitous fall in pulmonary function (FEV1)], cough, laryngeal edema (rare), nasal congestion (sometimes severe), pharyngeal irritation, and wheezing.

Adverse reactions which occur infrequently and are associated with administration of the drug are: anaphylaxis, angioedema, dizziness, dysuria and urinary frequency, joint swelling and pain, lacrimation, nausea and headache, rash, swollen parotid gland, urticaria, pulmonary infiltrates with eosinophilia, substernal burning, and myopathy.

The following adverse reactions have been reported as rare events and it is unclear whether they are attributable to the drug: anemia, exfoliative dermatitis, hemoptysis, hoarseness, myalgia, nephrosis, periarteritic vasculitis, pericarditis, peripheral neuritis, photodermatitis, sneezing, drowsiness, nasal itching, nasal bleeding, nasal burning, serum sickness, stomachache, polymyositis, vertigo, and liver disease.

Overdosage

There is no clinical syndrome associated with an overdosage of cromolyn sodium. In several animal species acute toxicity with cromolyn sodium occurs only with very high exposure levels. No deaths occurred at the highest oral doses tested in mice, 8000 mg/kg (approximately 5100 and 2700 times the maximum recommended daily inhalation doses in adults and children, respectively, on a mg/m2 basis) or in rats, 8000 mg/kg (approximately 10,000 and 5400 times the maximum recommended daily inhalation doses in adults and children, respectively, on a mg/m2 basis).

Dosage and Administration

For management of bronchial asthma in adults and pediatric patients (5 years of age and over) who are able to use the Inhaler, the usual starting dosage is two metered inhalations four times daily at regular intervals. This dose should not be exceeded. Not all patients will respond to the recommended dose and there is evidence to suggest, at least in younger patients, that a lower dose may provide efficacy.

Patients with chronic asthma should be advised that the effect of Intal Inhaler therapy is dependent upon its administration at regular intervals, as directed. Intal Inhaler should be introduced into the patient’s therapeutic regimen when the acute episode has been controlled, the airway has been cleared, and the patient is able to inhale adequately.

For the prevention of acute bronchospasm which follows exercise, exposure to cold, dry air, or environmental agents, the usual dose is two metered inhalations shortly before exposure to the precipitating factor, i.e., within 10 to 15 minutes but not more than 60 minutes.

Intal Inhaler Therapy in Relation to Other Treatments for Asthma:Non-steroidal agents:Intal Inhaler should be added to the patient’s existing treatment regimen (e.g., bronchodilators). When a clinical response to Intal Inhaler is evident, usually within two to four weeks, and if the asthma is under good control, an attempt may be made to decrease concomitant medication usage gradually.

If concomitant medications are eliminated or required on no more than a prn basis, the frequency of administration of Intal Inhaler may be titrated downward to the lowest level consistent with the desired effect. The usual decrease is from two metered inhalations four times daily to three times daily to twice daily. It is important that the dosage be reduced gradually to avoid exacerbation of asthma. It is emphasized that in patients whose dosage has been titrated to fewer than four inhalations per day, an increase in the dosage of Intal Inhaler and the introduction of, or increase in, symptomatic medications may be needed if the patient’s clinical condition deteriorates.

Corticosteroids: In patients chronically receiving corticosteroids for the management of bronchial asthma, the dosage should be maintained following the introduction of Intal Inhaler. If the patient improves, an attempt to decrease corticosteroids should be made. Even if the corticosteroid-dependent patient fails to show symptomatic improvement following Intal Inhaler administration, the potential to reduce corticosteroids may nonetheless be present. Thus, gradual tapering of corticosteroid dosage may be attempted. It is important that the dose be reduced slowly, maintaining close supervision of the patient to avoid an exacerbation of asthma.

It should be borne in mind that prolonged corticosteroid therapy frequently causes an impairment in the activity of the hypothalamic-pituitary-adrenal axis and a reduction in the size of the adrenal cortex. A potentially critical degree of impairment or insufficiency may persist asymptomatically for some time even after gradual discontinuation of adrenocortical steroids. Therefore, if a patient is subjected to significant stress, such as a severe asthmatic attack, surgery, trauma, or severe illness while being treated or within one year (occasionally up to two years) after corticosteroid treatment has been terminated, consideration should be given to reinstituting corticosteroid therapy. When respiratory function is impaired, as may occur in severe exacerbation of asthma, a temporary increase in the amount of corticosteroids may be required to regain control of the patient’s asthma.

It is particularly important that great care be exercised if for any reason cromolyn sodium is withdrawn in cases where its use has permitted a reduction in the maintenance dose of corticosteroids. In such cases, continued close supervision of the patient is essential since there may be sudden reappearance of severe manifestations of asthma which will require immediate therapy and possible reintroduction of corticosteroids.

For best results, the canister should be at room temperature before use.

How Supplied

Intal Inhaler is supplied as an aerosol canister which provides 112 metered dose actuations from the 8.1 gram inhaler and 200 metered dose actuations from the 14.2 gram inhaler. The correct amount of medication in each inhalation cannot be assured after 112 actuations from the 8.1 gram canister or 200 actuations from the 14.2 gram canister even though the canister may not feel completely empty. The canister should be discarded when the labeled number of actuations have been used.

Each actuation delivers 1 mg cromolyn sodium through the valve and 800 mcg through the mouthpiece to the patient. The Intal Inhaler canister and accompanying mouthpiece are designed to be used together. The Intal Inhaler canister should not be used with other mouthpieces and the supplied mouthpiece should not be used with other products’ canisters. Intal Inhaler is supplied with a white plastic mouthpiece with blue dust cap and patient instructions.

NDC 60793-011-14 ......................... 14.2 g canister

NDC 60793-011-08 .......................... 8.1 g canister

Store between 15° to 30°C (59° to 86°F). Contents under pressure. Do not puncture, incinerate, or place near sources of heat. Exposure to temperatures above 120°F may cause bursting. Avoid spraying in eyes. Keep out of the reach of children.

Note: The indented statement below is required by the Federal government’s Clean Air Act for all products containing or manufactured with chlorofluorocarbons (CFCs).

WARNING: Contains CFC-12 (dichlorodifluoromethane) and CFC-114 (dichlorotetrafluoroethane), substances which harm public health and the environment by destroying ozone in the upper atmosphere.

A notice similar to the above WARNING has been placed in the “Information For The Patient” portion of this package insert under the Environmental Protection Agency’s (EPA’s) regulations. The patient’s warning states that the patient should consult his or her physician if there are questions about alternatives.

Rx only

Intal® is a registered trademark of King Pharmaceuticals, Inc.

Distributed by: King Pharmaceuticals, Inc., Bristol, TN 37620

Manufactured by: Health Care Specialties Division, 3M Health Care Limited, Loughborough, England LE11 1EP

Made in United Kingdom.

Prescribing Information as of September 2005.

Information for Patients

Intal® INHALER (cromolyn sodium inhalation aerosol)

Metered Dose Inhaler

For Oral Inhalation Only

1. 
   

   Make sure the canister is properly inserted into the Inhaler unit. Take the cover off the mouthpiece. Shake the Inhaler gently. If the mouthpiece cover is not present, the Inhaler should be inspected for the presence of foreign objects.

   
   
   
   


2. 
   

   Hold Inhaler and breathe out slowly and fully, expelling as much air as possible. Do not breathe into the Inhaler– it could clog the Inhaler valve.

   
   


3. 
   

   Avoid spraying in eyes.

   
   
   
   


4. 
   

   Place the mouthpiece into your mouth, close your lips around it, and tilt your head back. Keep your tongue below the opening of the Inhaler.

   
   
   
   


5. 
   

   While breathing in deeply and slowly through the mouth, fully depress the top of the metal canister with your index finger.

   
   
   
   


6. 
   

   Remove the Inhaler from your mouth. Hold your breath for several seconds, then breathe out slowly. This step is very important. It allows the Intal to spread throughout your lungs. Repeat steps 2-5, then replace the mouthpiece cover.

   
   
   
   

FOR BEST RESULTS

1. 
   

   Before using the Inhaler for the first time, or if it has not been used for a while, it’s a good idea to test it. Just give the canister one press.

   
   


2. 
   

   It is essential that the canister be pressed at exactly the same time as you breathe in, so it’s worth some time practicing this.

   
   


3. 
   

   The dose delivered from the Inhaler can be seen as a fine white mist. If any of this can be seen escaping from your mouth or nose, then you are not using the Inhaler correctly.

   
   


4. 
   

   To keep your Inhaler in good working order, do not exhale into mouthpiece.

   
   


5. 
   

   Keep the cap on the Inhaler while not in use so that dirt can’t get into it. You can clean the Inhaler by removing the metal canister and rinsing the plastic mouthpiece in warm water. (See CLEANING Instructions.)

   
   


6. 
   

   The correct amount of medication in each inhalation cannot be assured after 112 actuations from the 8.1 gram canister or 200 actuations from the 14.2 gram canister even though the canister may not feel completely empty. You should keep track of the number of actuations used from each canister of Intal Inhaler and discard the canister after 112 actuations from the 8.1 gram canister or 200 actuations from the 14.2 gram canister. Before you reach the specified number of actuations, you should consult your physician to determine whether a refill is needed. Just as you should not take extra doses without consulting your physician, you also should not stop using Intal Inhalerwithout consulting your physician.

   
   


7. 
   

   For optimal results, the canister should be at room temperature before use.

   
   

HOW TO CHECK CONTENTS OF YOUR CANISTER

Shaking the canister will NOT give you a good estimate of how much medication is left. We have included a convenient check-off chart to assist you in keeping track of medication inhalations used. This will help assure that you receive the labeled number of inhalations present.

Each 8.1 gram Inhaler delivers 112 metered inhalations

Each 14.2 gram Inhaler delivers 200 metered inhalations

Intal® Inhaler Check-Off Chart

• 
  

  Retain with medication or affix to convenient location.

  
  

• 
  

  Starting with inhalation #1, check off one circle for each inhalation used.

  
  

• 
  

  DISCARD MEDICATION AFTER THE LABELED NUMBER OF INHALATIONS HAVE BEEN USED

  
  

• 
  

  NEVER IMMERSE THE METAL CANISTER IN WATER

  
  

IMPORTANT: Remember— a little time spent taking Intal correctly and regularly can save you from countless attacks of asthma and the upheaval they cause.

It must be used every day as directed by your doctor. Do not stop the treatment or even reduce the dose without consulting your doctor.

The Intal Inhaler canister and accompanying mouthpiece are designed to be used together. The Intal Inhaler canister should not be used with other mouthpieces and the supplied mouthpiece should not be used with other products’ canisters.

DOSAGE: For management of bronchial asthma in adults and children 5 years of age and older, the usual starting dosage is two metered inhalations four times a day at regular intervals. When asthma symptoms are well controlled, your doctor may reduce the dose to three times a day, and sometimes two times a day.

For prevention of acute bronchospasm which follows exercise, exposure to cold, dry air, or environmental agents, the usual dosage is two metered inhalations shortly before exposure to the offending factor.

Use as directed by your physician.

CLEANING: Twice a week, remove the metal canister from the plastic mouthpiece. Wash the mouthpiece in warm water and dry thoroughly before replacing the metal canister. Never immerse the metal canister in water.

STORAGE: Store between 15° to 30°C (59° to 86°F). Contents under pressure. Do not puncture, incinerate, or place near sources of heat. Exposure to temperatures above 120°F may cause bursting. Keep out of the reach of children. Avoid spraying in eyes.

Note: The indented statement below is required by the Federal Government’s Clean Air Act for all products containing or manufactured with chlorofluorocarbons (CFCs).

This product contains CFC-12 (dichlorodifluoromethane) and CFC-114 (dichlorotetrafluoroethane), substances which harm the environment by destroying ozone in the upper atmosphere.

Your physician has determined that this product is likely to help your personal health. USE THIS PRODUCT AS DIRECTED, UNLESS INSTRUCTED TO DO OTHERWISE BY YOUR PHYSICIAN. If you have any questions about alternatives, consult with your physician.

Intal® is a registered trademark of King Pharmaceuticals, Inc.

Distributed by: King Pharmaceuticals, Inc., Bristol, TN 37620

Manufactured by: Health Care Specialties Division, 3M Health Care Limited Loughborough, England LE11 1EP

Made in United Kingdom.

Prescribing Information as of September 2005.

Intal  cromolyn sodium  inhalant

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 60793-011 Route of Administration RESPIRATORY (INHALATION) DEA Schedule

INGREDIENTS Name (Active Moiety) Type Strength cromolyn sodium (cromolyn) Active 1 MILLIGRAM  In 1 INHALATION

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 60793-011-14 200 INHALATION In 1 CANISTER None 2 60793-011-08 112 INHALATION In 1 CANISTER None

Revised: 02/2007King Pharmaceuticals, Inc.

More Intal resources

• Intal Side Effects (in more detail)
• Intal Use in Pregnancy & Breastfeeding
• Intal Drug Interactions
• Intal Support Group
• 2 Reviews for Intal - Add your own review/rating

• Intal inhalation Concise Consumer Information (Cerner Multum)


• Intal Advanced Consumer (Micromedex) - Includes Dosage Information


• Intal Aerosol Solution MedFacts Consumer Leaflet (Wolters Kluwer)


• cromolyn Advanced Consumer (Micromedex) - Includes Dosage Information


• Cromolyn Sodium Monograph (AHFS DI)


• Gastrocrom Concentrate MedFacts Consumer Leaflet (Wolters Kluwer)


• Gastrocrom Concise Consumer Information (Cerner Multum)

Compare Intal with other medications

• Asthma, Maintenance

Gyno-Pevaryl 150 mg Vaginal Pessaries

Gyno-Pevaryl 150 vaginal pessaries

Econazole nitrate

Gyno-Pevaryl is a registered trademark

Read all of this leaflet carefully before you start using this medicine.

• Keep this leaflet. You may need to read it again



• If you have any further questions, ask your doctor or pharmacist



• This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours



• If you get side effects and they become serious or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist

In this leaflet

• 1. What Gyno-Pevaryl 150 pessaries are and what they are used for



• 2. Before you use Gyno-Pevaryl 150 pessaries



• 3. How to use Gyno-Pevaryl 150 pessaries



• 4. Possible side effects



• 5. How to store Gyno-Pevaryl 150 pessaries



• 6. Further information

What Gyno-Pevaryl 150 pessaries are and what they are used for

The name of your medicine is Gyno-Pevaryl 150 vaginal pessaries. They are called ‘Gyno-Pevaryl 150 pessaries' in this leaflet. This pack contains 3 pessaries.

Gyno-Pevaryl 150 pessaries are solid, torpedo-shaped pessaries (vaginal suppositories). When inserted into the vagina they release a medicine called econazole nitrate. This belongs to a group of medicines called ‘antifungals’.

Gyno-Pevaryl 150 pessaries are used for infections of the vagina and the skin around the vagina. The infections are caused by fungi and yeasts such as thrush (Candida).

Before you use Gyno-Pevaryl 150 pessaries

Do not use Gyno-Pevaryl 150 pessaries if:

• You are allergic to anything in Gyno-Pevaryl 150 pessaries (listed in section 6 below)



• You are allergic to any other medicine used to treat thrush or other fungal infections



• You are under 16 years old

Do not use this medicine if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before using Gyno-Pevaryl 150 pessaries.

Take special care with Gyno-Pevaryl 150 pessaries

Check with your doctor or pharmacist before using this medicine if:

• You are using a ‘barrier’ method of contraception. This includes condoms or diaphragms. This is because Gyno-Pevaryl 150 pessaries can damage the rubber and stop them working properly. Talk to your doctor about using another type of contraception while you are using this medicine

Taking other medicines

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines that you buy without a prescription or herbal medicines.

In particular tell your doctor if you are taking:

• Medicines to thin the blood (anticoagulants) such as warfarin or acenocoumarol

Pregnancy and breast-feeding

Please tell your doctor before using Gyno-Pevaryl 150 pessaries if you are pregnant, think you may be pregnant or might become pregnant.

You may still be able to use Gyno-Pevaryl 150 pessaries if your doctor thinks you need to.

Ask your doctor or pharmacist for advice before taking any medicine if you are pregnant or breast-feeding.

How to use Gyno-Pevaryl 150 pessaries

Always use this medicine exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.

Using the pessaries

• The full course is 3 pessaries



• Use one pessary each day, for 3 days



• Use the pessary just before going to bed. This helps it to stay in place



• Do not swallow the pessary

Inserting the pessary

• Tear down the groove between two individually wrapped pessaries



• Remove one pessary from its plastic packet using the easy open tab (figure 1)



• Lie down with your knees bent and spread apart



• Push the pessary with your forefinger as far as you can into your vagina (figure 2)

When to stop using Gyno-Pevaryl 150 pessaries

Use the full course of 3 pessaries. Do this, even if the soreness, itching and discharge go away before the end of the course.

If you swallow Gyno-Pevaryl 150 pessaries

If a pessary is eaten or swallowed talk to a doctor or go to the nearest hospital casualty department straight away.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Possible side effects

Like all medicines, Gyno-Pevaryl 150 pessaries can cause side effects, although not everybody gets them.

Stop using Gyno-Pevaryl 150 pessaries and tell your doctor straight away if you notice the following. You may need urgent medical treatment.

• Sudden swelling of the face or throat. Hives (also known as nettle rash or urticaria), severe irritation, reddening or blistering of your skin. These may be signs of a severe allergic reaction (affects less than 1 in 10,000 people)

Other side effects:

• Itchy and red skin around or inside the vagina. This is much milder than an allergic reaction. Tell your doctor or pharmacist if this feeling lasts for more than a few minutes or gets worse (rash, burning or swelling)

If you get side effects and they become serious or if you notice any other side effects not listed in this leaflet, please tell your doctor or pharmacist.

How to store Gyno-Pevaryl 150 pessaries

Keep out of the reach and sight of children. Store in the original container. Do not store above 30°C. Keep away from heat and sunlight.

Do not use Gyno-Pevaryl 150 pessaries:

• After the expiry date which is stated on the label. The expiry date refers to the last day of that month



• If the plastic packet is broken or missing



• If the pessaries are not white to off-white in colour

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

Further information

The active substance in Gyno-Pevaryl 150 pessaries is econazole nitrate. Each pessary contains 150 mg econazole nitrate.

The other ingredients are Wecobee M and Wecobee FS.

What Gyno-Pevaryl 150 pessaries looks like and contents of the pack

Gyno-Pevaryl 150 pessaries come in a plastic strip containing 3 pessaries. The pessaries are torpedo-shaped and white to off-white in colour.

The product licence is held by:

JANSSEN-CILAG LTD

50-100 Holmers Farm Way

High Wycombe

Bucks

HP12 4EG

UK

Gyno-Pevaryl 150 pessaries are made by:

Janssen Pharmaceutica NV

Turnhoutseweg 30

B-2340 Beerse

Belgium

OR

McGregor Cory Ltd

Middleton Close

Banbury

Oxon

OX16 4RS

UK

For information in large print, tape, CD or Braille, telephone 0800 7318450.

This leaflet was last approved in July 2008.

pralatrexate Intravenous

pral-a-TREX-ate

Commonly used brand name(s)

In the U.S.

• Folotyn

Available Dosage Forms:

• Solution

Pharmacologic Class: Antimetabolite

Uses For pralatrexate

Pralatrexate belongs to the group of medicines called antineoplastics. It is used to treat peripheral T-cell lymphoma (PTCL) in patients who have already been treated with other medicines that did not work well. Peripheral T-cell lymphoma is a rare type of cancer that affects certain white blood cells and causes enlarged and swollen lymph nodes in the neck, armpits, and groin.

Pralatrexate interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Some of these may be serious and must be reported to your doctor. Some effects may occur after treatment with pralatrexate.

pralatrexate is to be administered only by or under the immediate supervision of your doctor.

Before Using pralatrexate

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For pralatrexate, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to pralatrexate or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of pralatrexate in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pralatrexate in the elderly.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving pralatrexate, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using pralatrexate with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Probenecid

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of pralatrexate. Make sure you tell your doctor if you have any other medical problems, especially:

• Bone marrow problems (e.g., anemia, neutropenia, thrombocytopenia)—Use with caution. May make these conditions worse.

• Kidney disease or


• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of pralatrexate

It is very important to take folic acid and vitamin B12 during your treatment with pralatrexate to lower your chances of harmful side effects. You must start taking 1 to 1.25 milligrams (mg) of folic acid every day for at least 10 days before your first dose of pralatrexate. You must keep taking folic acid every day during the time you are getting treatment with pralatrexate, and for 30 days after your last treatment. You can get folic acid vitamins over-the-counter. Folic acid is also found in many multivitamin pills. Ask your doctor or pharmacist for help if you are not sure how to choose a folic acid product. Your doctor will give you vitamin B12 injections while you are getting treatment with pralatrexate. You will get your first vitamin B12 injection not more than 10 weeks before your first dose of pralatrexate, and then about every 8 to 10 weeks during treatment.

A nurse or other trained health professional will give you pralatrexate in a hospital or cancer treatment center. pralatrexate is given through a needle placed in one of your veins.

Precautions While Using pralatrexate

It is very important that your doctor check your progress at regular visits to make sure that pralatrexate is working properly. Blood tests may be needed to check for unwanted effects.

Make sure your doctor knows if you are pregnant before you receive pralatrexate. If you are a woman of childbearing potential, you should use two forms of birth control together to avoid getting pregnant while you are receiving pralatrexate. If you have become pregnant during your treatment, tell your doctor right away.

Pralatrexate can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

• If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.


• Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in the urine or stools; or pinpoint red spots on your skin.


• Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.


• Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.


• Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.

pralatrexate may cause mucositis, which is redness or sores on the inside of the mouth or tongue. Check with your doctor right away if you have cracked lips, diarrhea, difficulty with swallowing, or sores, ulcers, or white spots on the lips, tongue, or inside of the mouth while you are using pralatrexate.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

pralatrexate Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Black, tarry stools


• bleeding gums


• blood in the urine or stools


• body aches or pain


• chills


• convulsions


• cough


• cracked lips


• decreased urine


• diarrhea


• difficult or labored breathing


• difficulty with swallowing


• dry mouth


• ear congestion


• fast, pounding, or irregular heartbeat or pulse


• fever


• headache


• increased thirst


• loss of appetite


• loss of voice


• lower back or side pain


• mood changes


• muscle pain or cramps


• nasal congestion


• nausea or vomiting


• numbness or tingling in the hands, feet, or lips


• painful or difficult urination


• pale skin


• pinpoint red spots on the skin


• runny nose


• shortness of breath


• sneezing


• sore throat


• sores, ulcers, or white spots on the lips, tongue, or inside the mouth


• swelling


• tightness in the chest


• troubled breathing with exertion


• unusual bleeding or bruising


• unusual tiredness or weakness


• wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Abdominal or stomach pain


• back pain


• bloody nose


• constipation


• itching skin


• lack or loss of strength


• night sweats


• pain in the arms or legs


• rash


• weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: pralatrexate Intravenous side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More pralatrexate Intravenous resources

• Pralatrexate Intravenous Side Effects (in more detail)
• Pralatrexate Intravenous Use in Pregnancy & Breastfeeding
• Pralatrexate Intravenous Drug Interactions
• Pralatrexate Intravenous Support Group
• 0 Reviews for Pralatrexate Intravenous - Add your own review/rating

Compare pralatrexate Intravenous with other medications

• Lymphoma
• Non-Hodgkin's Lymphoma
• Peripheral T-cell Lymphoma